retinol binding proteins การใช้

• Retinol then attaches to a serum carrier, retinol binding protein, for transport to target tissues.
• It then enters the RPE cells, and is transferred to the Cellular Retinol Binding Protein ( CRBP ) chaperone.
• CRABP2 is specifically co-expressed with RAR-? and cellular retinol binding protein 1 genes in certain tissues.
• With PEM the synthesis of retinol binding protein ( RBP ) is decreased, consequently the uptake of retinol is reduced ( Combs, 1991 ).
• After intake, they are converted to retinol, successively metabolized, and finally bound to retinol binding proteins ( lipocalins ) in the blood plasma.
• The physiologic basis lies in pregnancy whereby the mutated gene product, retinol binding protein ( RBP ), has negative effects in transferring vitamin A from maternal liver storage sites to the placenta, and then again on the fetal circulation side when delivering vitamin A from the placenta to developing fetal tissues, most notably the developing eye.
• An examination of the interstitial retinol binding protein nuclear gene ( IRBP ) in three marmoset species showed that " Callithrix " as constructed in the 1990s also needed to include " C . pygmaea " to be monophyletic, and that the times of separation of " pygmaea " and the " argentata " and " jacchus " species groups from one another are less than 5 million years ago, as might be expected for species of the same genus.